CALL FOR PAPERS How Genes Influence Renal Function and Disease Estrogen receptor -mediated events promote sex-specific diabetic glomerular hypertrophy
نویسندگان
چکیده
Alecia S. Lovegrove, Jianhong Sun, Karen A. Gould, Dennis B. Lubahn, Kenneth S. Korach, and Pascale H. Lane Department of Pediatrics and Eppley Research Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198; Departments of Biochemistry and Child Health, University of Missouri, Columbia, Missouri 65211; and National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
منابع مشابه
Estrogen Receptor α Mediated Events Promote Sex- Specific Diabetic Glomerular Hypertrophy
Sex differences in the incidence and progression of renal diseases suggest a protective role for estrogen. This study examined the role of estrogen receptor α (ERα)-mediated events in normal and diabetic renal and glomerular growth. Wild-type and ERα null mice (ERKO) were observed over 2 weeks of streptozocin-induced diabetes. Blood glucose was monitored, and insulin given daily to maintain lev...
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IT IS WELL ESTABLISHED THAT cardiovascular disease is a leading cause of death in developed countries, but it is less well known that more women than men die of cardiovascular disease, although these deaths are delayed by 10 yr (7, 17). It is becoming evident that there is considerable sexual dimorphism in the pathogenesis of cardiovascular disease. Thus findings from past studies, mostly in ma...
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Diabetic kidney disease is the leading cause of end-stage renal disease. Podocytes are differentiated cells necessary for the development and maintenance of the glomerular basement membrane and the capillary tufts, as well as the function of the glomerular filtration barrier. The epithelial glomerular cells express a local renin-angiotensin system (RAS) that varies in different pathological sit...
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Simonson MS, Tiktin M, Debanne SM, Rahman M, Berger B, Hricik D, Ismail-Beigi F. The renal transcriptome of db/db mice identifies putative urinary biomarker proteins in patients with type 2 diabetes: a pilot study. Am J Physiol Renal Physiol 302: F820–F829, 2012. First published December 28, 2011; doi:10.1152/ajprenal.00424.2011.—We sought to identify novel urinary biomarkers of kidney function...
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The mechanisms underlying glomerular hypertrophy and hyperfiltration in diabetes remain unclear. We have previously demonstrated that the cytokine transforming growth factor-β1 (TGF-β1) is increased in early diabetic kidney disease and TGF-β1 inhibits the expression of the inositol 1,4,5-trisphosphate (IP3)-gated calcium channel, the type I IP3 receptor (IP3R), in mesangial cells. To test the h...
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